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Author: R. L. Melnick
Publisher: DIANE Publishing
Keywords: studies, b6c3f1, rats, mice, water, drinking, f344, acid, toxicology, report, carcinogenesis, bromochloroacetic, technical, cas
Number of Pages: 302
Published: 2009-09
ISBN-10: 1437914551
ISBN-13: 9781437914559

Bromochloroacetic acid is a water disinfection by-product. Bromochloroacetic acid was nominated for toxicity and carcinogenicity studies in rats and mice because of widespread human exposure and because a related dihaloacetate, dichloroacetate, was found to be carcinogenic to the liver of rats and mice. Drinking water was selected as the route of exposure to mimic human exposure to this chemical. Male and female F344/N rats and B6C3F1 mice were exposed to bromochloroacetic acid (greater than 95% pure) in drinking water for 2 weeks, 3 months, or 2 years. Genetic toxicology studies were conducte
2403

Author: D. W. Bristol
Publisher: DIANE Publishing
Keywords: studies, rats, f344, b6c3f1, gavage, mice, cas, blue, toxicology, report, carcinogenesis, methylene, technical, trihydrate
Number of Pages: 252
Published: 2008-10-01
ISBN-10: 1437906613
ISBN-13: 9781437906615

Methylene Blue Trihydrate (MBT) has a variety of biomedical and biologically therapeutic applications. MBT was nominated by the Nat. Cancer Inst. for carcinogenecity testing based on the numerous uses of this compound and the lack of long-term toxicity data, including epidemiological studies of MBT, as well as the inadequate animal data on this compound. Male and female F344/N rats and B6C3F1 mice were administered MBT in 0.5% aqueous methylcellulose by gavage for 1 month, 3 months, or 2 years. Genetic toxicology studies were conducted using ¿Salmonella typhimurium,¿ ¿Escherichia coli,¿ cu
2400

Author: M. E. Wyde
Publisher: DIANE Publishing
Keywords: studies, rats, b6c3f1, mice, inhalation, f344, methylstyrene, report, toxicology, carcinogenesis, technical, cas
Number of Pages: 464
Published: 2008-04-01
ISBN-10: 1428988866
ISBN-13: 9781428988866

a-Methylstyrene is used to make heat-resistant acrylonitrile-butadiene-styrene resins & polymers. This report studies the effects of a-methylstyrene on male & female rats & mice to identify potential toxic or cancer-related hazards. It concludes that exposure to a-methylstyrene in the air caused kidney tumors, & possibly mononuclear cell leukemia, in male rats. It concludes that a-methylstyrene caused liver cancer in female mice, & also possibly in male mice. Charts, tables, graphs & plates.
2952

Author: P. C. Chan
Publisher: DIANE Publishing
Keywords: studies, rats, b6c3f1, mice, inhalation, f344, cumene, report, toxicology, carcinogenesis, technical, cas
Number of Pages: 206
Published: 2009-09
ISBN-10: 1437914543
ISBN-13: 9781437914542

Cumene is produced in a modified Friedel-Crafts reaction process. Cumene is the principal chemical used in the production of phenol and acetone. Cumene is used: as a thinner; as a constituent of some petroleum-based solvents; in gasoline blending, diesel fuel, and high-octane aviation fuel; and as a raw material for peroxides and oxidation catalysts. Because cumene is a good solvent for fats and resins, it has been suggested as a replacement for benzene in many industrial applications. Cumene occurs naturally in petroleum and in a variety of foodstuffs. Cumene was nominated for study because o
2516

Author: Michael L. Cunningham
Publisher: DIANE Publishing
Keywords: toxicity, rats, b6c3f1, mice, hamsters, syrian, dawley, male, studies, report, cas, administered, feed, sprague
Number of Pages: 90
Published: 2008-03-01
ISBN-10: 1428988130
ISBN-13: 9781428988132

Wyeth-14,643 is a chemical that was developed by the pharmaceutical industry to lower serum cholesterol. It is not used in clinical applications. This study examined the effects of Wyeth-14,643 on rats, mice, & hamsters because it was known that this chemical promotes the production of peroxisomes, organelles that contain a variety of enzymes involved in metabolism of lipids & cholesterols. Results show that exposure to Wyeth-14,6453 caused changes in the livers of male rats, mice, & hamsters, including increased liver weights, increases in cytoplasmic alteration of the liver, & some liver foc
8002

Author: M. J. Hooth
Publisher: DIANE Publishing
Keywords: studies, b6c3f1, f344, rats, mice, water, drinking, cas, dihydrate, toxicology, report, carcinogenesis, sodium, dichromate, technical
Number of Pages: 200
Published: 2009-02-01
ISBN-10: 1437908209
ISBN-13: 9781437908206

Chromium is a metal that exists in a variety of valence states, depending on surrounding conditions and what other atoms it is bound to. The most stable forms are metallic chromium, trivalent chromium (chromium III), and hexavalent chromium (chromium VI). Chromium VI has been shown to cause cancer when inhaled in the air. Because compounds containing chromium VI occur as contaminants in drinking water, scientists studied the effects of sodium dichromate dihydrate (SDD) in drinking water on rats and mice to identify potential toxic or cancer-related hazards. Results showed that rats exposed to
9545

Author: R. D. Irwin
Publisher: DIANE Publishing
Keywords: studies, rats, b6c3f1, mice, gavage, f344, formamide, report, toxicology, carcinogenesis, technical, cas
Number of Pages: 174
Published: 2009-02
ISBN-10: 1437908292
ISBN-13: 9781437908299

Formamide has a variety of uses, including as a softener for paper, gums, and glues. This report details the study of the effects of formamide on male and female rats and mice to identify potential toxic or cancer-related hazards. Solutions containing formamide in deionized water were deposited directly into the stomachs of male and female rats and mice. Groups of 50 animals received 20, 40, or 80 milligrams of formamide per kilogram body weight 5 days per week for 2 years; groups of animals receiving water alone served as the control groups. At the end of the study, tissues from more than 40
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